Molecular mechanisms of BK channel function and subcellular localization
报告题目:Molecular mechanisms of BK channel function and subcellular localization
报告人:Dr. Zhaowen Wang(王肇文教授,Department of Neuroscience ,University of Connecticut)
报告时间: 2015年9月24日(星期四)上午9:20-10:20
报告地点: 医学院综合楼701会议室
主持人: 康利军 教授
简介:
Ca2+ plays key roles in neurotransmitter release. It triggers the release by directly binding to Ca2+ sensor(s) at the presynaptic site, and regulates the release by modulating the activities of several presynaptic proteins. We study the functions of presynaptic voltage-gated Ca2+ channels, ryanodine receptor (a Ca2+-releasing channel in the endoplasmic reticulum membrane), BK channel (a large-conductance Ca2+-activated K+ channel), and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in neurotransmitter release, and try to determine whether and how these proteins interact at the presynaptic site. These research programs have the potential to significantly advance our understanding of the molecular mechanisms of synaptic transmission.