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Lijun Kang's Group Published in Neuron on Glial GABA Signaling
2024-03-08
Glial cells play a crucial role in the development, function, and health of the nervous system and brain. From Caenorhabditis elegans, Drosophila to zebrafish, mice, and humans, the origin, structure, and function of glial cells have been highly conserved [1].On March 6, 2024, Professor Lijun Kang and his team published a research article titled "Phasic/Tonic-like Glial GABA Differential...Glial cells play a crucial role in the development, function, and health of the nervous system and brain. From Caenorhabditis elegans, Drosophilato zebrafish, mice, and humans, the origin, structure, and function of glial cells have been highly conserved [1].On March 6, 2024, Professor Lijun Kang and his team published a research article titled Phasic/Tonic-like Glial GABA Differentially Transduce for Olfactory Adaptation and Neuronal Aging in the journal Neuron. In their study, they discovered
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Yanqin Yu’s group published in National Science Review on neuromechanism of defensive behavior
2024-03-08
The research team led by Prof. Yan-qin Yu has recently published an article titled Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons in National Science Review on Mar 5th, Beijing time. This research identifies a previously unrecognized role for the lPAGglu-NDGABA-GiVglu pathway in controlling defensive behaviors.Threatening situations, ...The research team led by Prof. Yan-qin Yuhas recently published an article titledControl of defensive behavior by the nucleus of Darkschewitsch GABAergic neuronsinNational Science Reviewon Mar 5th, Beijing time. This research identifies a previously unrecognized role for the lPAGglu-NDGABA-GiVglupathway in controlling defensive behaviors.Threatening situations, such as the presence of a predator or exposure to stimuli predicting imminent or perceived danger, evoke an evolutionarily conserved bra
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Xiao-Ming Li’s group published in Nature Neuroscience on neuromechanism of fear and anxiety
2024-02-14
Excessive or repetitive fear play a significant role in the development of anxiety disorders, with the amygdala serving as the central locus for fear processing. Clinical research has demonstrated that individuals with bilateral amygdala damage are still capable of experiencing fear, indicating the amygdala may not be absolutely required for fear. To date, the neural mechanisms underlying fear tha...Excessive or repetitive fear play a significant role in the development of anxiety disorders, with the amygdala serving as the central locus for fear processing. Clinical research has demonstrated that individuals with bilateral amygdala damage are still capable of experiencing fear, indicating the amygdala may not be absolutely required for fear. To date, the neural mechanisms underlying fear that are independent of the amygdala are still poorly understood.On February 12th, Prof. LI Xiao-Ming a
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Binggui Sun'group published in PNAS on new mechanisms underlying the excitability of CA2 pyramidal neurons and social recognition
2024-01-11
Social behaviors such as social interaction, recognition and memory are critical for daily life of animals including human beings, and social deficits including social withdraw, anxiety and isolation are closely associated with psychological or neurological disorders1. Therefore, it is important to elucidate the mechanisms of social behaviors. It has been well known that anterior cingul...Social behaviors such as social interaction, recognition and memory are criticalfor daily life of animals including human beings, and social deficits including social withdraw, anxiety and isolation are closely associated with psychological or neurological disorders1. Therefore, it is important to elucidate the mechanisms of social behaviors. It has been well known that anterior cingulate cortex (ACC) is a social hub in the brain2, and recent studies demonstrate that hippocampal CA2 pyramidal ne
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XiaoMing Li’s group published in Cell on cannabinoid receptor
2023-12-18
The joint research team led by Prof. Xiao-Ming Li and Prof. Yan Zhang has recently published an article entitled Snapshot of the cannabinoid receptor 1–arrestin complex unravels the biased signaling mechanism on Cell online on Dec 14th, 2023. Addressing the long-standing Cannabis problem, an oddity that has vexed scientists for decades, this research achieved a breakthrough by unraveling...The joint research team led by Prof. Xiao-Ming Li and Prof. Yan Zhang has recently published an article entitled Snapshot of the cannabinoid receptor 1–arrestin complex unravels the biased signaling mechanismon Cell online on Dec 14th, 2023. Addressing the long-standing Cannabisproblem, an oddity that has vexed scientists for decades, this research achieved a breakthrough by unraveling signaling bias mechanism toward cannabinoid receptor 1 (CB1), facilitating safer synthetic cannabinoid targetin
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Hao Wang’s group published in Science Advances on energy homeostasis
2023-11-02
The research team led by Prof. Hao Wang has recently published an article titled “Neural adaption in midbrain GABAergic cells contributes to high-fat-diet induced obesity” in Science Advances.In modern society, high-calorie food is readily available and easily accessible, leading to a steady increase in the incidence of obesity. Obesity, in turn, contributes to the rise of other rel... The research team led by Prof. Hao Wang has recently published an article titled “Neural adaption in midbrain GABAergic cells contributes to high-fat-diet induced obesity” in Science Advances.In modern society, high-calorie food is readily available and easily accessible, leading to a steady increase in the incidence of obesity. Obesity, in turn, contributes to the rise of other related diseases such as hypertension, hyperlipidemia, and diabetes, placing a significant burden to both society and
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Hailan Hu's group published in Nature on ketamine
2023-10-19
The research team led by Prof. Hailan Hu has recently published an article titled Sustained Antidepressant Effect of Ketamine through NMDAR Trapping in the LHb on Nature online on Oct 18th, 2023. This research revealed ketamine trapped in NMDAR to mediate the mechanism of the sustained antidepressant effects of ketamine.The use-dependent trapping properties of ketamine for NMDAR are the ...The research team led by Prof. Hailan Huhas recently published an article titled Sustained Antidepressant Effect of Ketamine through NMDAR Trapping in the LHbon Nature online on Oct 18th, 2023. This research revealed ketamine trapped in NMDAR to mediate the mechanism of the sustained antidepressant effects of ketamine.The use-dependent trapping properties of ketamine for NMDAR is the essence ofits sustained antidepressant effects.Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, has
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Hailan Hu's group published in Neuron on stress relief
2023-10-03
The research team led by Prof. Hailan Hu has recently published an article titled Stress Relief as a Natural Resilience Mechanism against Depression-like Behaviors on Neuron online on Sep 29th, 2023. This research discovered relief as a natural resilience mechanism against depression, and deconstructed the neural circuit mechanisms underlying relief.Unraveling relief as a homeo...The research team led by Prof.Hailan Huhas recently published an article titledStress Relief as a Natural Resilience Mechanism against Depression-like Behaviorson Neuron online on Sep 29th, 2023. This research discovered relief as a natural resilience mechanism against depression, and deconstructed the neural circuit mechanisms underlying relief.Unraveling relief as a homeostatic defense mechanism for mood regulation and clarifying the underlying neural circuit mechanismRelief, the appetitive st
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XiaoMing Li’s group published in Biological Psychiatry on distinct fear modulation
2023-09-12
The research team led by Prof. Xiao-Ming Li has recently published an article titled Distinct Circuits from Central Lateral Amygdala to Ventral Part of Bed Nucleus of Stria Terminalis Regulate Different Fear Memory in Biological Psychiatry on Sep 5th, Beijing time.This research established a functional role for distinct central lateral amygdala to ventral part of stria terminalis ci...The research team led by Prof. Xiao-Ming Li has recently published an article titledDistinct Circuits from Central Lateral Amygdala to Ventral Part of Bed Nucleus of Stria Terminalis Regulate Different Fear MemoryinBiological Psychiatry on Sep 5th, Beijing time.This research established a functional role for distinct central lateral amygdala to ventral part of stria terminalis circuits in the differential regulation and appropriate maintenance of fear.The ability to differentiate stimuli predict
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Lixia Gao’s group published in National Science Review on neural representation of conspecific vocalizations in amygdala of awake marmosets
2023-08-23
The research team led by Prof. Lixia Gao has recently published an article titled Representation of conspecific vocalizations in amygdala of awake marmoset in National Science Review on Jul 13th, Beijing time. This research uncovered a novel role of amygdala in representing a critical stage of socially relevant auditory perception. Human speech and animal vocalizations are important for socia...The research team led by Prof. Lixia Gao has recently published an article titled Representation of conspecific vocalizations in amygdala of awake marmoset in National Science Review on Jul 13th, Beijing time. This research uncovered a novel role of amygdala in representing a critical stage of socially relevant auditory perception.Human speech and animal vocalizations are important for social communication and animal survival. Neurons in the auditory pathway are responsive to a range of sounds,
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Hongbin Yang’s group published in Neuronon on motivation
2023-07-27
The research team led by Prof. Hongbin Yang has recently published an article titled Dopamine Release and Negative Valence Gated by Inhibitory Neurons in the Laterodorsal Tegmental Nucleus in Neuron on July 26, 2023, Beijing time. This research uncovered separate GABAergic subpopulations in a single brainstem nucleus that relay unpleasant stimuli to the mesolimbic DA system through direc...The research team led by Prof. Hongbin Yang has recently published an article titled Dopamine Release and Negative Valence Gated by Inhibitory Neurons in the Laterodorsal Tegmental NucleusinNeuron on July 26, 2023, Beijing time. This research uncovered separate GABAergic subpopulations in a single brainstem nucleus that relay unpleasant stimuli to the mesolimbic DA system through direct and indirect projections, which is critical for establishing a circuit-level understanding of how negative val
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Xuhua Wang's group published in Nature Communications
2023-07-11
AbstractOn July 7th, 2023, Xuhua Wang's research group at Zhejiang University School of Medicine published a study titled Porous microneedle patch with sustained extracellular vesicles delivery mitigates severe spinal cord injury in Nature Communications. This team fabricated a porous microneedle patch based on mesenchymal stem cells (MN-MSC) containing mesenchymal stem cells and mic...AbstractOn July 7th, 2023, Xuhua Wangs research group at Zhejiang University School of Medicine published a study titled Porous microneedle patch with sustained extracellular vesicles delivery mitigates severe spinal cord injuryin Nature Communications.This team fabricated a porous microneedle patch based on mesenchymal stem cells (MN-MSC) containing mesenchymal stem cells and microneedle arrays for delivering extracellular vesicles to spinal cord injury sites for treatment. The microneedle arra
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Xuhua Wang’s group published in Nature Nanotechnology on severe spinal cord injury
2023-06-13
On June 12, 2023, Xuhua Wang’s research group published a study entitled "Controlled delivery of a neurotransmitter-agonist conjugate for functional recovery after severe spinal cord injury" in Nat. Nanotechnol. The team developed an intravenous nano drug that targets inhibitory neurons to regulate their overexcited state by balancing disrupted residual spinal cord loops, providing neur...On June 12, 2023, Xuhua Wang’s research group published a study entitled Controlled delivery of a neurotransmitter-agonist conjugate for functional recovery after severe spinal cord injury in Nat. Nanotechnol. The team developed an intravenous nano drug that targets inhibitory neurons to regulate their overexcited state by balancing disrupted residual spinal cord loops, providing neuroprotection by regulating the injury environment, and ultimately promoting the recovery of motor function after s
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Xiaotong Zhang’s group published in NeuroImage on multimodal neuroimaging
2023-06-06
The research team led by Prof. Xiaotong Zhang has recently published an research article titled “Design and application of a multimodality-compatible 1Tx/6Rx RF coil for monkey brain MRI at 7T” on NeuroImage on May 25. This study proposed a RF coil design for macaque whole-brain imaging that is compatible with multiple neuroimaging and neuromodulation techniques. Blood-oxygen-level-de...The research team led by Prof. Xiaotong Zhang has recently published an research article titled “Design and application of a multimodality-compatible 1Tx/6Rx RF coil for monkey brain MRI at 7T” on NeuroImage on May 25. This study proposed a RF coil design for macaque whole-brain imaging that is compatible with multiple neuroimaging and neuromodulation techniques.Blood-oxygen-level-dependent functional MRI allows to investigte neural activities and connectivity. While the non-human primate plays
