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Zhihua Gao' s group published in Current Biology on general anesthesia
2023-05-15
On May 10, the research team led by Prof. GAO Zhihua at the Zhejiang University School of Brain Science and Brain Medicine published an open-access article titled “Microglia modulate general anesthesia through P2Y12 receptor” in the journal Current Biology. It is the first time that scientists have uncovered the function of microglia in regulating general anesthesia...On May 10, the research team led by Prof.GAO Zhihuaat the Zhejiang UniversitySchool of Brain Science and Brain Medicinepublished an open-access article titled “Microglia modulate general anesthesia through P2Y12receptor” in the journalCurrent Biology. It is the first time that scientists have uncovered the function of microglia in regulating general anesthesia via the P2Y12receptor.General anesthesia, which can induce reversible unconsciousness, is extensively used in modern surgeries and relate
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Aimin Bao's group published in Alzheimer’s and Dementia on sex differences in aging
2023-03-27
Alzheimer's disease (AD) is the most common type of dementia in the elderly and poses a heavy health burden to the patients and the society. Women have a higher prevalence of AD than men, and a faster decline and deterioration of cognitive functions. The entorhinal cortex (EC) is one of the earliest structures affected in AD. In recent postmortem human brain research, the team led b...Alzheimers disease (AD) is the most common type of dementia in the elderly and poses a heavy health burden to the patients and the society. Women have a higher prevalence of AD than men, and a faster declineand deterioration of cognitive functions. The entorhinal cortex (EC) is one of the earliest structures affected in AD. In recent postmortem human brain research, the team led by Prof Ai-Min Bao, from the School of Brain Science and BrainMedicine of Zhejiang University in close collaboration w
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Zhihua Gao's group published in eLife on defensive behavior
2023-03-20
The research team led by Prof. Zhihua Gao has recently published an article titled A parabrachial to hypothalamic pathway mediates defensive behavior in eLife on Mar 17th, Beijing time. This research identifies a previously unrecognized role for the LPBCCK-PVN pathway in controlling defensive behaviors.It is the nature of animals to seek profit and avoid harm. In different environments, animals ma...The research team led by Prof. Zhihua Gao has recently published an article titled A parabrachial to hypothalamic pathway mediates defensive behavior in eLife on Mar 17th, Beijing time. This research identifies a previously unrecognized role for the LPBCCK-PVN pathway in controlling defensive behaviors.It is the nature of animals to seek profit and avoid harm. In different environments, animals may adopt different defensive behaviors when they encounter threats. Both the paraventricular nucleus
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Shuang Qiu's group published in Biological Psychiatry on fear extinction
2023-03-03
The research team led by Prof. Shuang Qiu has recently published an article titled NMDAR-dependent synaptic potentiation via APPL1 signaling is required for the accessibility of a prefrontal neuronal assembly in retrieving fear extinction in Biological Psychiatry onFeb24th, Beijing time. This research identifies a cellular and molecular mechanism underlying fear extinction, whi...The ventromedial prefrontal cortex (vmPFC) has been viewed as a locus to store and recall extinction memory. However, the synaptic and cellular mechanisms underlying this process remain elusive. We combined transgenic mice, electrophysiological recording, activity-dependent cell labeling, and chemogenetic manipulation to analyze the role of adaptor protein APPL1 in the vmPFC for fear extinction retrieval. We found that both constitutive and conditional APPL1 knockout decreases NMDA receptor (NMD
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Binggui Sun'group published in Cell Reports on hyperexcitability of CA1 PNs in AD mice
2023-02-24
The team led by Prof. Binggui Sun recently published an article titled Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer’s disease on Mar. 28, 2023, Beijing time. This study identifies new pathways accounting for hyperexcitability of CA1 pyramidal neurons in AD mice.Hyperactivity of pyramidal neurons (PN...The team led by Prof.Binggui Sun recently published an article titledAberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer’s diseaseon Mar. 28, 2023, Beijing time.This study identifies new pathways accounting for hyperexcitability of CA1 pyramidal neurons in AD mice.Hyperactivity of pyramidal neurons (PNs) in CA1 is an early event in Alzheimer’s disease (AD). However, factors accounting for the hyperactivity of CA1 PNs remain
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Xiaoming Li's group published in Cell Discovery on amygdala evolution
2023-02-15
The research team led by Prof. Xiaoming Li has recently published an article titled Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profifiling in Cell Discoveryon Feb.14th, Beijing time. This research uncovered evolutionaryconservation and divergence of the amygdala across species, and laid a solid foundation for fu...The research team led by Prof. Xiaoming Lihas recently published an article titledMolecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profifilinginCell Discoveryon Feb.14th, Beijing time. This research uncovered evolutionaryconservation and divergenceof the amygdala across species, and laid a solid foundation for future studies of the amygdala function at the cell type level.The amygdala, or an amygdala-like structure, is found in the brains o
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Ge Bai's group published in Cell on peripheral neuropathy
2023-02-15
On February 3, 2023, Prof.BAI Ges research group fromthe School of Brain Science and Brain Medicine, Zhejiang UniversitySchool of Medicine, and LI Jinsongs research group from the CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences published a cover article inCell, entitled “Diverse CMT2 Neuropathies are Linked to Aberrant G3BP Interactions in Stress Granules”. This study reveals that the stress granules abnormality is the common pathogenic mechanism underlying diffe
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Hailan Hu's group published in Cell on social-status-loss-induced depression
2023-02-08
Alpha is the “king” of a horde of mice. While meeting another mouse in the pipeline, Alpha can scare it away with merely a glance. But one day the situation changes. With unexpected courage, the little “mouse brother” pushes Alpha out of the way directly after confronting the “king” for several seconds. After experiencing the Waterloo for several successive days, Alpha becomes depressed and loses his previous dominance.This reversal was orchestrated by a cohort of brain scientists who witnessed
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Dan Wu's group published in Neuro-Oncology
2023-01-12
On January 7, 2023, Professor Dan Wu's team from the College of Biomedical Engineering and Instrument Science at Zhejiang University, in collaboration with Dr. Hongxi Zhang's team from the Department of Radiology at Zhejiang University Children's Hospital, published a paper titled Histological and Molecular Classifications of Pediatric Glioma with Time-depen... On January 7, 2023, Professor Dan Wus team from the College of Biomedical Engineering and Instrument Science at Zhejiang University, in collaboration with Dr. Hongxi Zhangs team from the Department of Radiology at Zhejiang University Childrens Hospital, published a paper titled Histological and Molecular Classifications of Pediatric Glioma with Time-dependent Diffusion MRI based Microstructural Mapping in the journal Neuro-Oncology. The team introduced a non-invasive microstructural mapping
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Anna Wang Roe and Jiaming Hu's group published in eLife on spatial frequency
2023-01-09
The research team of Professor Anna Wang Roe and Jiaming Hu has recently published an article entitled "Spatial frequency representation in V2 and V4 of Macaque monkey" online in the internationally renowned journal eLife on Jan 6, 2023. This research revealed how spatial frequenciesare encoded and coordinated with other features in V2 and V4 of Macaque monkey.Spatial frequency (SF)...The research team of Professor Anna Wang Roe and Jiaming Hu has recently published an article entitled Spatial frequency representation in V2 and V4 of Macaque monkey online in the internationally renowned journal eLife on Jan 6, 2023. This researchrevealed how spatial frequenciesare encoded and coordinated with other features in V2 and V4 of Macaque monkey.Spatial frequency (SF) is an important attribute in the visual scene and is a defining feature of visual processing channels. Previous studi
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XinYi Lai's group published in Asian Journal Of Psychiatry
2022-12-30
Dr. Hsin-Yi Lai, Dr. Tao Li and Dr. Wenxin Tang collaborated to explore structural and functional alterations in drug-naïve obsessive-compulsive disorder patients by 7.0T multimodal magnetic resonance imaging. Their findings were published in an internationally renowned journal “Asian Journal of Psychiatry” in December. 2023. This study comprehensively revealed not onl... Dr. Hsin-Yi Lai, Dr. Tao Li and Dr. Wenxin Tang collaborated to explore structural and functional alterations in drug-naïve obsessive-compulsive disorder patients by 7.0T multimodal magnetic resonance imaging. Their findings were published in an internationally renowned journal “Asian Journal of Psychiatry” in December. 2023. This study comprehensively revealed not only the classical cortico-striatal-thalamic-cortical (CSTC) circuit, but also limbic system, default network, visual, language,
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