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Hailan Hu's group published in Science on ketamine
2024-08-13
The research team led by Prof. Hailan Hu has recently published an article titled Brain region–specific action of ketamine as a rapid antidepressant on Science online on Aug 9th, 2024. This research revealed ketamine blocks NMDARs in vivo in a brain region– and depression state–specific manner.The use-dependent nature of ketamine as an NMDAR blocker converges with local brain r...The research team led by Prof. Hailan Huhas recently published an article titled Brain region–specific action of ketamine as a rapid antidepressanton Science online on Aug 9th, 2024. This research revealed ketamine blocks NMDARs in vivo in a brain region– and depression state–specific manner.The use-dependent nature of ketamineas an NMDAR blocker converges with localbrain region properties to distinguish the LHbas a primary brain target of ketamine action.Ketamine has been found to have rapid an
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Ke Jia's group published in Science Advances on human brain plasticity
2024-08-01
The research team led by Dr. Ke Jia published an article titled “Recurrent inhibition refines mental templates to optimize perceptual decisions” in Science Advances on July 31, 2024. This study capitalises onstate-of-the-art ultra-high-field (7T) multimodal brain imaging approach and reveals a recurrent inhibitory plasticity mechanism for optimized perceptual decisions.The idea th...The research team led by Dr. Ke Jia published an article titled “Recurrent inhibition refines mental templates to optimize perceptual decisions” inScience Advanceson July 31, 2024. This study capitalises onstate-of-the-art ultra-high-field (7T) multimodal brain imaging approach and reveals a recurrent inhibitory plasticity mechanism for optimizedperceptual decisions.The idea that the brain solves complex tasks by forming mental templates—that is, internal representations of key information relev
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Han Xu’s group published in Brain on social fear
2024-07-31
The research team led by Professors Han Xu and Yuzheng Hu published an article titled “A Prefrontal-Habenular Circuitry Regulates Social Fear Behavior” in Brain on July 4, 2024. This study elucidates the critical role of the prefrontal-habenular circuitry in modulating social fear.Social behaviors are vital for survival and reproduction across species, evolving dynamically based on social e...The research team led by Professors Han Xu and Yuzheng Hu published an article titled “A Prefrontal-Habenular Circuitry Regulates Social Fear Behavior” in Brainon July 4, 2024. This study elucidates the critical role of the prefrontal-habenular circuitry in modulating social fear.Social behaviors are vital for survival and reproduction across species, evolving dynamically based on social experiences. Clinically, intense social fear is a prevalent symptom in various mental disorders, highlighting
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Shumin Duan and Yanqin Yu’s group published in Neuron on sexually dimorphic aggressive behavior
2024-07-17
In July 16, 2024, Neuron published the latest research by Professor Shumin Duan and Yanqin Yu's team from the School of Brain Science and Brain Medicine at Zhejiang University. The article, entitled “A Hypothalamic-Amygdala Circuit Underlying Sexually Dimorphic Aggression,” identifies a hypothalamic-amygdala circuit that mediates male-biased aggression in mice.Mammals have evolved sexual rep...In July 16, 2024, Neuron published the latest research by Professor Shumin Duan and Yanqin Yus team from the School of Brain Science and Brain Medicine at Zhejiang University. The article, entitled “A Hypothalamic-Amygdala Circuit Underlying Sexually Dimorphic Aggression,” identifies a hypothalamic-amygdala circuit that mediates male-biased aggression in mice.Mammals have evolved sexual reproduction to achieve higher evolutionary potential and adapt to environmental changes, resulting in an effi
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Han Xu’s group published in Nature Communications on social fear
2024-05-17
The research team led by Prof. Han Xu has recently published an article titled ‘The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation’ on Nature Communications online on May 13, 2024. This research discovered a novel neural circuit mechanism of glutamatergic neurons in the basal forebrain (BF) mediating social behavioral maladaptation through their proje...The research team led by Prof. Han Xu has recently published an article titled ‘The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation’ on Nature Communicationsonline on May 13, 2024. This research discovered a novel neural circuit mechanism of glutamatergic neurons in the basal forebrain (BF) mediating social behavioral maladaptation through their projection to the lateral habenula (LHb).In our daily life, we spend around 80% of our waking time in social rela
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Fang Guo's Group Published in Nature Communications on Temperature and Sleep
2024-04-07
On April 2, Fang Guo's research group at the School of Brain Science and Brain Medicine at Zhejiang University published a research paper titled "Dynamic Encoding of Temperature in the Central Circadian Circuit Coordinates Physiological Activities" in the prestigious journal "Nature Communications". Employing advanced experimental techniques, the study unveiled the pi...On April 2, Fang Guos research group at the School of Brain Science and Brain Medicine at Zhejiang University published a research paper titled Dynamic Encoding of Temperature in the Central Circadian Circuit Coordinates Physiological Activities in the prestigious journal Nature Communications. Employing advanced experimental techniques, the study unveiled the pivotal temperature-sensing circadian neuron DN1a in Drosophila, capable of rhythmically responding to environmental temperature fluctuat
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Jianhong Luo's Group Published in Molecular Psychiatry on cognitive inflexibility in ASD mice model
2024-04-02
Jianhong Luo lab from the School of Brain Science and Brain Medicine at Zhejiang University published a paper in Molecular Psychiatry, revealing the mechanisms of frontal-striatal circuit dysfunction that lead to cognitive inflexibility in the autism mouse model NL3R451C. Cognitive flexibility is an important component of executive function, enabling animals to respond appropriately to constantly ...Jianhong Luo lab from the School of Brain Science and Brain Medicine at Zhejiang University published a paper in Molecular Psychiatry, revealing the mechanisms of frontal-striatal circuit dysfunction that lead to cognitive inflexibility in the autism mouse model NL3R451C. Cognitive flexibility is an important component of executive function, enabling animals to respond appropriately to constantly changing environment. Autism Spectrum Disorder (ASD) is characterized by social deficit, repetitive,
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Xiaotong Zhang’s group published in Nature Communications on UHF MRI
2024-03-20
The research team led by Prof. Xiaotong Zhang has recently published a research article titled “Subwavelength Dielectric Waveguide for Efficient Travelling-Wave Magnetic Resonance Imaging” on Nature Communications on March 14. This study proposed a modified Travelling-Wave system using a subwavelength dielectric waveguide insert that enhances both efficiency and homogeneity at 7T MRI. &nbs...The research team led by Prof. Xiaotong Zhang has recently published a research article titled “Subwavelength Dielectric Waveguide for Efficient Travelling-Wave Magnetic Resonance Imaging” on Nature Communications on March 14. This study proposed a modified Travelling-Wave system using a subwavelength dielectric waveguide insert that enhances both efficiency and homogeneity at 7T MRI. Uniform excitation of nuclei spins through circular-polarized transverse magnetic component of electromagnetic f
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Lijun Kang's Group Published in Neuron on Glial GABA Signaling
2024-03-08
Glial cells play a crucial role in the development, function, and health of the nervous system and brain. From Caenorhabditis elegans, Drosophila to zebrafish, mice, and humans, the origin, structure, and function of glial cells have been highly conserved [1].On March 6, 2024, Professor Lijun Kang and his team published a research article titled "Phasic/Tonic-like Glial GABA Differential...Glial cells play a crucial role in the development, function, and health of the nervous system and brain. From Caenorhabditis elegans, Drosophilato zebrafish, mice, and humans, the origin, structure, and function of glial cells have been highly conserved [1].On March 6, 2024, Professor Lijun Kang and his team published a research article titled Phasic/Tonic-like Glial GABA Differentially Transduce for Olfactory Adaptation and Neuronal Aging in the journal Neuron. In their study, they discovered
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Yanqin Yu’s group published in National Science Review on neuromechanism of defensive behavior
2024-03-08
The research team led by Prof. Yan-qin Yu has recently published an article titled Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons in National Science Review on Mar 5th, Beijing time. This research identifies a previously unrecognized role for the lPAGglu-NDGABA-GiVglu pathway in controlling defensive behaviors.Threatening situations, ...The research team led by Prof. Yan-qin Yuhas recently published an article titledControl of defensive behavior by the nucleus of Darkschewitsch GABAergic neuronsinNational Science Reviewon Mar 5th, Beijing time. This research identifies a previously unrecognized role for the lPAGglu-NDGABA-GiVglupathway in controlling defensive behaviors.Threatening situations, such as the presence of a predator or exposure to stimuli predicting imminent or perceived danger, evoke an evolutionarily conserved bra
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Xiao-Ming Li’s group published in Nature Neuroscience on neuromechanism of fear and anxiety
2024-02-14
Excessive or repetitive fear play a significant role in the development of anxiety disorders, with the amygdala serving as the central locus for fear processing. Clinical research has demonstrated that individuals with bilateral amygdala damage are still capable of experiencing fear, indicating the amygdala may not be absolutely required for fear. To date, the neural mechanisms underlying fear tha...Excessive or repetitive fear play a significant role in the development of anxiety disorders, with the amygdala serving as the central locus for fear processing. Clinical research has demonstrated that individuals with bilateral amygdala damage are still capable of experiencing fear, indicating the amygdala may not be absolutely required for fear. To date, the neural mechanisms underlying fear that are independent of the amygdala are still poorly understood.On February 12th, Prof. LI Xiao-Ming a
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Binggui Sun'group published in PNAS on new mechanisms underlying the excitability of CA2 pyramidal neurons and social recognition
2024-01-11
Social behaviors such as social interaction, recognition and memory are critical for daily life of animals including human beings, and social deficits including social withdraw, anxiety and isolation are closely associated with psychological or neurological disorders1. Therefore, it is important to elucidate the mechanisms of social behaviors. It has been well known that anterior cingul...Social behaviors such as social interaction, recognition and memory are criticalfor daily life of animals including human beings, and social deficits including social withdraw, anxiety and isolation are closely associated with psychological or neurological disorders1. Therefore, it is important to elucidate the mechanisms of social behaviors. It has been well known that anterior cingulate cortex (ACC) is a social hub in the brain2, and recent studies demonstrate that hippocampal CA2 pyramidal ne
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XiaoMing Li’s group published in Cell on cannabinoid receptor
2023-12-18
The joint research team led by Prof. Xiao-Ming Li and Prof. Yan Zhang has recently published an article entitled Snapshot of the cannabinoid receptor 1–arrestin complex unravels the biased signaling mechanism on Cell online on Dec 14th, 2023. Addressing the long-standing Cannabis problem, an oddity that has vexed scientists for decades, this research achieved a breakthrough by unraveling...The joint research team led by Prof. Xiao-Ming Li and Prof. Yan Zhang has recently published an article entitled Snapshot of the cannabinoid receptor 1–arrestin complex unravels the biased signaling mechanismon Cell online on Dec 14th, 2023. Addressing the long-standing Cannabisproblem, an oddity that has vexed scientists for decades, this research achieved a breakthrough by unraveling signaling bias mechanism toward cannabinoid receptor 1 (CB1), facilitating safer synthetic cannabinoid targetin
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Hao Wang’s group published in Science Advances on energy homeostasis
2023-11-02
The research team led by Prof. Hao Wang has recently published an article titled “Neural adaption in midbrain GABAergic cells contributes to high-fat-diet induced obesity” in Science Advances.In modern society, high-calorie food is readily available and easily accessible, leading to a steady increase in the incidence of obesity. Obesity, in turn, contributes to the rise of other rel... The research team led by Prof. Hao Wang has recently published an article titled “Neural adaption in midbrain GABAergic cells contributes to high-fat-diet induced obesity” in Science Advances.In modern society, high-calorie food is readily available and easily accessible, leading to a steady increase in the incidence of obesity. Obesity, in turn, contributes to the rise of other related diseases such as hypertension, hyperlipidemia, and diabetes, placing a significant burden to both society and
