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Jiadong Chen' group published in Journal of Clinical Investigation on molecular markers of neuronal senescence in human drug-resistant epilepsy
2025-03-10
Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain and is often accompanied by symptoms such as cognitive impairment, anxiety, depression, and autism, severely affecting patients' quality of life. Globally, approximately 70 million people suffer from epilepsy, with an incidence rate of about 6.4 per 1,000 people. Among them, around 30% do not resp...Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain and is often accompanied by symptoms such as cognitive impairment, anxiety, depression, and autism, severely affecting patients quality of life. Globally, approximately 70 million people suffer from epilepsy, with an incidence rate of about 6.4 per 1,000 people. Among them, around 30% do not respond to existing antiepileptic drugs and are classified as drug-resistant epilepsy, though its exact patho
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Lijun Kang's group published in Nature Communications on mechanosensation
2025-02-27
Mechanotransduction plays a critical role in various physiological processes, including hearing, touch, proprioception, pain, and blood pressure regulation. Mechanogated ion channels function as mechanoreceptors, converting mechanical forces into electrical signals to transduce force information. To date, all known mechanotransduction channels in the animal kingdom are either cation channels or ch...Mechanotransduction plays a critical role in various physiological processes, including hearing, touch, proprioception, pain, and blood pressure regulation. Mechanogated ion channels function as mechanoreceptors, converting mechanical forces into electrical signals to transduce force information. To date, all known mechanotransduction channels in the animal kingdom are either cation channels or channels permeable to cations (such as Piezo1/2, TMC1, TRP-4/NomPC/TRPN, ENaC, TMEM63, and K2P), with
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MA Huan's group published in Science on mechanisms underlying dynamic brain energy supply
2024-12-19
Prof. MA Huan's team at Zhejiang University investigated the relationship between neuroplastic regulation of bioenergetics and cognitive aging. Their findings, published in Science under the title Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice, provide a novel perspective and theoretical framework for understanding energy-effici...Prof.MAHuans team at Zhejiang University investigated the relationship between neuroplastic regulation of bioenergetics and cognitive aging. Their findings, published in Scienceunder the title Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice, provide a novel perspective and theoretical framework for understanding energy-efficient neural computation and combating cognitive aging.As the core organ governing thought and consciousness, the brain consu
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Hailan Hu's group published in Neuron on neural mechanism underlying social hierarchy
2024-12-11
The research team led by Prof. Hailan Hu has recently published an article titled Deconstructing the neural circuit underlying social hierarchy in mice on Neuron online on Dec 10th, 2024. This research revealed the antagonistic interplay between win-related and lose-related dmPFC downstream pathways in mediating social competition.Social competition determines hierarchical soci...The research team led by Prof.Hailan Huhas recently published an article titledDeconstructing the neural circuit underlying social hierarchy in miceon Neuron online on Dec 10th, 2024. This research revealed the antagonistic interplay between win-related and lose-related dmPFC downstream pathways in mediating social competition.Social competition determines hierarchical social status, which profoundly influences animals’ behavior and health. The dorsomedial prefrontal cortex (dmPFC) plays a funda
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Shumin Duan and Yan-qin Yu 's group published in Advanced Science on astrocytes and arousal
2024-11-05
The research team led by Prof. Shumin Duan and Yan-qin Yu has recently published a study in Advanced Science titled Adenosine‐Dependent Arousal Induced by Astrocytes in a Brainstem Circuit on October 16, 2024 This study provides the first evidence that astrocytes in the brainstem parafacial zone (PZ) play a unique role in promoting and sustaining wakefulness through extrac...The research team led by Prof. Shumin Duan and Yan-qin Yuhasrecentlypublished a study in Advanced Sciencetitled Adenosine‐Dependent Arousal Induced by Astrocytes in a Brainstem Circuiton October 16, 2024 This study provides the first evidence that astrocytes in the brainstem parafacial zone (PZ) play a unique role in promoting and sustaining wakefulness through extracellular adenosine and elucidates the underlying circuit-level mechanisms.Astrocytes play a crucial role in regulating sleep-wake b
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Xiao-Ming Li and Jiadong Chen 's group published in Advanced Science on the neural mechanism of amygdala in regulating temporal lobe epilepsy
2024-11-01
The research team led by Prof. Xiao-Ming Li and Jiadong Chen has recently published an article titled Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy in Advanced Science on October 30, 2024. This research revealed the pBLA as a pivotal nucleus in the amygdaloid complex for regulating epileptic seizures in TLE.The amygdaloid complex consis...The research team led by Prof.Xiao-Ming Li and Jiadong Chenhas recently published an article titledPosterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsyin Advanced Science on October 30, 2024. This research revealed the pBLA as a pivotal nucleus in the amygdaloid complex for regulating epileptic seizures in TLE.The amygdaloid complex consists of multiple nuclei and is a key node in controlling temporal lobe epilepsy (TLE) in both human and animal model studies.
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Hailan Hu's group published in Science on ketamine
2024-08-13
The research team led by Prof. Hailan Hu has recently published an article titled Brain region–specific action of ketamine as a rapid antidepressant on Science online on Aug 9th, 2024. This research revealed ketamine blocks NMDARs in vivo in a brain region– and depression state–specific manner.The use-dependent nature of ketamine as an NMDAR blocker converges with local brain r...The research team led by Prof. Hailan Huhas recently published an article titled Brain region–specific action of ketamine as a rapid antidepressanton Science online on Aug 9th, 2024. This research revealed ketamine blocks NMDARs in vivo in a brain region– and depression state–specific manner.The use-dependent nature of ketamineas an NMDAR blocker converges with localbrain region properties to distinguish the LHbas a primary brain target of ketamine action.Ketamine has been found to have rapid an
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Ke Jia's group published in Science Advances on human brain plasticity
2024-08-01
The research team led by Dr. Ke Jia published an article titled “Recurrent inhibition refines mental templates to optimize perceptual decisions” in Science Advances on July 31, 2024. This study capitalises onstate-of-the-art ultra-high-field (7T) multimodal brain imaging approach and reveals a recurrent inhibitory plasticity mechanism for optimized perceptual decisions.The idea th...The research team led by Dr. Ke Jia published an article titled “Recurrent inhibition refines mental templates to optimize perceptual decisions” inScience Advanceson July 31, 2024. This study capitalises onstate-of-the-art ultra-high-field (7T) multimodal brain imaging approach and reveals a recurrent inhibitory plasticity mechanism for optimizedperceptual decisions.The idea that the brain solves complex tasks by forming mental templates—that is, internal representations of key information relev
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Han Xu’s group published in Brain on social fear
2024-07-31
The research team led by Professors Han Xu and Yuzheng Hu published an article titled “A Prefrontal-Habenular Circuitry Regulates Social Fear Behavior” in Brain on July 4, 2024. This study elucidates the critical role of the prefrontal-habenular circuitry in modulating social fear.Social behaviors are vital for survival and reproduction across species, evolving dynamically based on social e...The research team led by Professors Han Xu and Yuzheng Hu published an article titled “A Prefrontal-Habenular Circuitry Regulates Social Fear Behavior” in Brainon July 4, 2024. This study elucidates the critical role of the prefrontal-habenular circuitry in modulating social fear.Social behaviors are vital for survival and reproduction across species, evolving dynamically based on social experiences. Clinically, intense social fear is a prevalent symptom in various mental disorders, highlighting
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Shumin Duan and Yanqin Yu’s group published in Neuron on sexually dimorphic aggressive behavior
2024-07-17
In July 16, 2024, Neuron published the latest research by Professor Shumin Duan and Yanqin Yu's team from the School of Brain Science and Brain Medicine at Zhejiang University. The article, entitled “A Hypothalamic-Amygdala Circuit Underlying Sexually Dimorphic Aggression,” identifies a hypothalamic-amygdala circuit that mediates male-biased aggression in mice.Mammals have evolved sexual rep...In July 16, 2024, Neuron published the latest research by Professor Shumin Duan and Yanqin Yus team from the School of Brain Science and Brain Medicine at Zhejiang University. The article, entitled “A Hypothalamic-Amygdala Circuit Underlying Sexually Dimorphic Aggression,” identifies a hypothalamic-amygdala circuit that mediates male-biased aggression in mice.Mammals have evolved sexual reproduction to achieve higher evolutionary potential and adapt to environmental changes, resulting in an effi
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Han Xu’s group published in Nature Communications on social fear
2024-05-17
The research team led by Prof. Han Xu has recently published an article titled ‘The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation’ on Nature Communications online on May 13, 2024. This research discovered a novel neural circuit mechanism of glutamatergic neurons in the basal forebrain (BF) mediating social behavioral maladaptation through their proje...The research team led by Prof. Han Xu has recently published an article titled ‘The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation’ on Nature Communicationsonline on May 13, 2024. This research discovered a novel neural circuit mechanism of glutamatergic neurons in the basal forebrain (BF) mediating social behavioral maladaptation through their projection to the lateral habenula (LHb).In our daily life, we spend around 80% of our waking time in social rela
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Fang Guo's Group Published in Nature Communications on Temperature and Sleep
2024-04-07
On April 2, Fang Guo's research group at the School of Brain Science and Brain Medicine at Zhejiang University published a research paper titled "Dynamic Encoding of Temperature in the Central Circadian Circuit Coordinates Physiological Activities" in the prestigious journal "Nature Communications". Employing advanced experimental techniques, the study unveiled the pi...On April 2, Fang Guos research group at the School of Brain Science and Brain Medicine at Zhejiang University published a research paper titled Dynamic Encoding of Temperature in the Central Circadian Circuit Coordinates Physiological Activities in the prestigious journal Nature Communications. Employing advanced experimental techniques, the study unveiled the pivotal temperature-sensing circadian neuron DN1a in Drosophila, capable of rhythmically responding to environmental temperature fluctuat
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Jianhong Luo's Group Published in Molecular Psychiatry on cognitive inflexibility in ASD mice model
2024-04-02
Jianhong Luo lab from the School of Brain Science and Brain Medicine at Zhejiang University published a paper in Molecular Psychiatry, revealing the mechanisms of frontal-striatal circuit dysfunction that lead to cognitive inflexibility in the autism mouse model NL3R451C. Cognitive flexibility is an important component of executive function, enabling animals to respond appropriately to constantly ...Jianhong Luo lab from the School of Brain Science and Brain Medicine at Zhejiang University published a paper in Molecular Psychiatry, revealing the mechanisms of frontal-striatal circuit dysfunction that lead to cognitive inflexibility in the autism mouse model NL3R451C. Cognitive flexibility is an important component of executive function, enabling animals to respond appropriately to constantly changing environment. Autism Spectrum Disorder (ASD) is characterized by social deficit, repetitive,
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Xiaotong Zhang’s group published in Nature Communications on UHF MRI
2024-03-20
The research team led by Prof. Xiaotong Zhang has recently published a research article titled “Subwavelength Dielectric Waveguide for Efficient Travelling-Wave Magnetic Resonance Imaging” on Nature Communications on March 14. This study proposed a modified Travelling-Wave system using a subwavelength dielectric waveguide insert that enhances both efficiency and homogeneity at 7T MRI. &nbs...The research team led by Prof. Xiaotong Zhang has recently published a research article titled “Subwavelength Dielectric Waveguide for Efficient Travelling-Wave Magnetic Resonance Imaging” on Nature Communications on March 14. This study proposed a modified Travelling-Wave system using a subwavelength dielectric waveguide insert that enhances both efficiency and homogeneity at 7T MRI. Uniform excitation of nuclei spins through circular-polarized transverse magnetic component of electromagnetic f
