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Dr. Shumin Duan/'s group published in Nature Communication
2017-02-06
Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Tan, Z. Liu Y, Xi W, Lou HF, Zhu L, Guo Z, Mei L, Duan. Nat. Commun. 8, 13772 doi: 10.1038/ncomms13772 (2017). Abstract: Astrocyte responds to neuronal activity with calcium waves and modulates synaptic transmission through the release of gliotransmitters. However, little is known a... Glia-derived ATP inversely regulates excitability
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Dr. Yudong Zhou/'s group published in Journal of Cell Biology
2016-11-10
Shen Y, Qin H, Chen J, Mou L, He Y, Yan Y, Zhou H, Lv Y, Chen Z, Wang J, Zhou YD.Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons.J Cell Biol. 2016 Dec 5;215(5):719-734. Epub 2016 Nov 10. Abstract: Astrocytes are critical in synapse development, and their dy... Shen Y, Qin H, Chen J, Mou L,
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Dr. Zhong Chen/'s group published in Pain
2016-10-15
ZhangSH, YuJ, LouGD, TangYY, WangRR, HouWW, Chen Z.Widespread pain sensitization after partial infraorbital nerve transection in MRL/MPJ mice.Pain. 2016 Mar;157(3):740-9. Abstract: Clinical studies show that chronic pain can spread to adjacent or even distant body regions in some patients. However, little is known about ho... ZhangSH, YuJ, LouGD, TangYY,
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Dr. Zhong Chen/'s group published in Brain Behavior and Immunity
2016-10-14
Zhou Y, Zhang J, Wang L, Chen Y, Wan Y, He Y, Jiang L, Ma J, Liao R, Zhang X, Shi L, Qin Z, Zhou Y, Chen Z, Hu W.Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.Brain Behav Immun. 2016 Sep 20. Abstract: Subcortical ische... Zhou Y, Zhang J, Wang L, Chen
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Dr. Shumin Duan and Dr. Hao Wang/'s group published in eLife
2016-04-13
Yang J, Yang H, Liu Y, Li X, Qin L, Lou H, Duan S, Wang H.Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP.Elife. 2016 Apr 12;5:e15043. doi: 10.7554/eLife.15043. Abstract: Selective elimination of unwanted synapses is vital for the precise formation of neuronal circuits during development,... Yang J, Yang H, Liu Y, Li X,
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Dr. Xiaoming Li/'s group published in eLife
2016-02-12
Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. Kun-Ming Ni, Xiao-Jun Hou, Ci-Hang Yang, Ping Dong, Yue Li, Ying Zhang, Ping Jiang, Darwin K Berg, Shumin Duan, Xiao-Ming Li. DOI: http://dx.doi.org/10.7554/eLife.10382 Abstract: Cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (... Selectively driving cholinergic fibers optically
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Dr. Shumin Duan and Dr. Hao Wang/'s group published in Nature Neuroscience
2016-01-05
Yang H, Yang J, Xi W, Hao S, Luo B, He X, Zhu L, Lou H, Yu YQ, Xu F, Duan S, Wang H.Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.Nat Neurosci. 2016 Feb;19(2):283-9. doi: 10.1038/nn.4208. Epub 2016 Jan 4. Abstract: Innate fear has a critical role in survival of animal... Yang H, Yang J, Xi W, Hao S,
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Dr. Zhefeng Gong/'s group published in Nature Communication
2015-12-17
Li Q, Gong Z. Cold-sensing regulates Drosophila growth through insulin-producing cells.Nat Commun. 2015 Dec 9;6:10083. Abstract: Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger body sizes than those observed at higher temperatures. The underlying molecular basis of this effect is poorly understood. Here we provide ev... Li Q, Gong Z. Cold-sensing regulates Drosoph
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Dr. Ying Shen/'s group published in PNAS
2015-12-03
Zhou L, Yang D, Wang DJ, Xie YJ, Zhou JH, Zhou L, Huang H, Han S, Shao CY, Li HS, Zhu JJ, Qiu MS, De Zeeuw CI, Shen Y. Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination. Proc Natl Acad Sci U S A. 2015 Nov 30. pii: 201512915. Abstract: Protein Numb controls cell fate by interacting with a number of signaling molecules,... Zhou L, Yang D, Wang DJ, Xie YJ, Zhou JH, Zhou L,
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How success feeds success-- mouse study may tell how
2015-07-14
Getting to the top of social hierarchy is often not a matter of body size or brute strength, but rather determined by intrinsic mental factors such as grit, as well as extrinsic factors such as history of winning. For example, social dominance can be reinforced by a phenomenon known as the “winner effect”, whereby animals increase their probability of victory after previous winnings. H... Getting to the top of social hierarchy is often n
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Dr. Jianhong Luo/'s group published in Cell Research
2015-06-26
Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory.Cell Res. 2015 Jul;25(7):818-36. doi: 10.1038/cr.2015.75. Epub 2015 Jun 19. Abstract : The N-methyl-D-aspartate receptor (NMDAR) in adult forebrain is a heterotetramer mainly composed of two GluN1 subunits and two GluN2A... Activity-induced synaptic delivery of the GluN2A-
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Dr. Shumin Duan/'s group published in the Jounal of Neuroscience
2015-04-13
A study from Professor Shumin Duan’s group on how an intracellular size filter enhances antigen processing in microglia was recently published on The Journal of Neuroscience Abstract: Microglia are the primary immune cells in the brain. Theycontinually survey the brain microenvironment and uptake cell debris and aberrant proteins to maintain brain homeostasis. Recent studies have shown that... A study from Professor Shumin Duan’s group
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Dr. Jizeng Du and Xuequn Chen/'s group published in Diabetes
2015-03-31
Hao K, Kong FP, Gao YQ, Tang JW, Chen J, Evans AM, Lightman SL, Chen XQ, Du JZ . Inactivation of Corticotropin-Releasing Hormone-Induced Insulinotropic Role by High-Altitude Hypoxia..Diabetes. 64: 785-795.2014 Abstract: We have shown that hypoxia reduces plasma insulin, which correlates with corticotropin-releasing hormone (CRH) receptor 1 (CRHR1) in rats, but the mechanis... Hao K, Kong FP, Gao YQ, Tang JW, Chen J, Evans AM
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Dr. Ying Shen/'s group published in Scientific Reports (NPG)
2015-01-20
On Jan 16 2015, Scientific Reports(Nature Publishing Group) published an original research article from Ying Shen’s group. The title is “Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum”. In the textbook, LGI1 is a classical gene that is tightly linked to human autosomal dominant lateral temporal lobe epilepsy (ADLTE). ... On Jan 16 2015, Scientific Reports(Nature Publish
