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Dr. Xiaoming Li’s group published in Nature Medicine
2019-01-15
Recently, Xiao-Ming Li, a professor at Zhejiang University School of Medicine, made a major breakthrough in the study of depression. The study foundthe new molecular- and circuit- mechanism mediating the pathogenesis of depression. The relevant paper were published in the January 15th issue of Nature Medicine. In a five-year study, the Xiao-Ming Liteam focused on a brain area called... Recently, Xiao-Ming Li, a professor at Zhejiang U
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Dr. Zhefeng Gong/'s group published in Nature Communications
2019-01-10
On Jan 10, 2019, two groups led by Professor Zhefeng Gong and Associate Professor Nenggan Zheng, respectively from the Institute of Neuroscience and Qiushi Academy of Zhejiang University published their joint research article titled as “A disinhibitory mechanism biases Drosophila innate light preference” on Nature Communications. In this research, they discovered a key neural mechanism... On Jan 10, 2019, two groups led by Professor Zhef
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Dr. Xiaoming Li’s group published in Neuron
2019-01-10
Activating a neural pathway from the Ventral Tegmental Area (VTA) to the Dorsal Raphe Nucleus (DRN) could significantly reduce morphine addiction while not affecting its analgesic effect, suggests new research led by Prof. LI Xiaoming from ZJU’s School of Medicine. The study, published in the January 10 issue of Neuron, found two parallel inhibitory neural pathways from VTA t... Activating a neural pathway from the Ventral Tegm
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Dr. Lijun Kang/'s group published in Nature Communications
2018-10-17
On Oct 17, 2018, Professor Lijun Kang’s research group from Zhejiang University in China published a research article entitled “Decoding the intensity of sensory input by two glutamate receptors in one C. elegansinterneuron”(Wenjuan Zou, et al.)in the journal Nature Communications. How neurons are capable of decoding stimulus intensity and translate this information into complex ... On Oct 17, 2018, Professor Lijun Kang’s res
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Dr. Xiaoming Li’s group published in eLife
2018-10-14
Bipolar disorder is a mental illness that affects roughly 1 in 100 people worldwide. It features periods of depression interspersed with episodes of mania – a state of delusion, heightened excitation and increased activity. Evidence suggests that changes in a brain region called the locus coeruleus contribute to bipolar disorder. Cells within this area produce a chemical called norepinephrin... Bipolar disorder is a mental illness that affects
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Dr. Fang Guo’s group published in Neuron
2018-09-27
On September 27, 2018, a research paper entitled A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila was published on from Fang Guo’s lab in the Department of Neuroscience of Zhejiang University School of Medicine. This study identified a neural circuit of Drosophila linking circadian neuron APDN1 to the sleep center ellipsoid body EB-R2. The result discovered the mechanism... On September 27, 2018, a research paper entitled
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Dr. Fan Yang’s group published in Nature Communications
2018-07-23
On July 23rd 2018, a research paper titled “The conformational wave in capsaicin activation of Transient Receptor Potential Vanilloid 1 ion channel” has been published in Nature Communications from Dr. Fan Yang’s group. In this study, with a combination of fluorescent unnatural amino acid imaging, computational structural modeling and single-channel patch-clamp recording, they ob... On July 23rd 2018, a research paper titled &ldquo
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Dr. Huan Ma/'s team published in Nature Communications
2018-06-22
Unable to carry signals based on sights and sounds to the genes that record memories, a broken shuttle protein may hinder learning in patients with intellectual disability, schizophrenia and autism. This is the implication of a study led by researchers at Zhejiang UniversitySchool of Medicine and NYU School of Medicine, which ispublished online June 22th in Nature Communications. Specifical... Unable to carry signals based on sights and sound
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Dr. Yuezhou Li/'s Team published in Cell Reports
2018-04-10
On 4/3/2018, the Cell Reports published online a research article entitled “Brv1 is required for Drosophila larvae to sense gentle touch” from Prof. Li’s group. How we sense touch is fundamental for many physiological processes. However, the underlying mechanism and molecular identity for touch sensation are largely unknown. In this study, Li's group reports defective gentle-... On 4/3/2018, the Cell Reports published online a
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Dr. Ying Shen/'s Team published in Journal of Neuroscience
2018-03-21
On 2/28/2018, the Journal of Neuroscience published online a research article entitled “Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy” from Prof. Shen’s group. This study reveals that the cause of seizures in Autosomal Dominant Lateral Temporal Lobe Epilepsy (ADLTE) is the increased discharges of cortical pyramidal neurons, the under... On 2/28/2018, the Journal of Neuroscience publish
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Two back-to-back Nature Articles form Hailan Hu/'s Team on Depression and Ketamine
2018-02-15
On Feb 14, 2018, Nature published online two Research Articles side-by-side from Professor Hailan Hu’s team in the Medical School of Zhejiang University. They reported a series of discoveries pertaining the rapid antidepressant mechanism of ketamine, the abnormal neural coding pattern and neuron-glia interaction underlying depression. Classical antidepressants... On Feb 14, 2018, Nature published online&n
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Dr. Hailan Hu/'s Team published in Science
2017-07-14
Getting to the top of social hierarchy is often not a matter of body size or brute strength, but rather determined by intrinsic mental factors such as grit, as well as extrinsic factors such as history of winning. For example, social dominance can be reinforced by a phenomenon known as the “winner effect”, whereby animals increase their probability of victory after previous winnings. H... Getting to the top of social hierarchy is often n
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Dr. Weiping Zhang/'s group published in PNAS
2017-06-19
Dong X, Gong Z, Lu Y B, Liu K, Qin L Y, Ran M L, Zhang C L, Liu Z, Zhang W P, and Tang C. Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci U S A, 2017 Jun 13. Abstract: Ubiquitin (Ub) is an important signaling protein. Recent studies showed that Ub can be enzymatically phosphorylated at S65, and the resulting pUb exhibits t... Dong X, Gong Z, Lu Y B, Liu K, Qin L Y, Ran M L,
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Dr.Binggui Sun/'s group published in FASEB Journal
2017-03-06
A new study from laboratories of Dr. Binggui Sun and collaborators demonstrated that brain-specific ablation of Efr3a promoted adult hippocampal neurogenesis via brain derived neurotrophic factor pathway. Efr3 is a newly identified plasma membrane protein and plays an important role in the phosphoinositide metabolism on the plasma membrane. However, although it is highly expressed in the br... A new study from laboratories of Dr. Bingg
