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Dr. Jianhong Luo/'s group published in Cell Death and Disease
2014-12-02
TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death Dis. 2014 Nov 27. Abstract: Transient ischemia is a leading cause of cognitive dysfunction. Postischemic ROS generation and an increase in the cytosolic Zn2+ level ([Zn2+]c) are critical in delayed CA1 pyramidal neuronal death, but the underlying mechan... TRPM2 channel deficiency prevents delayed cytosol
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Dr. Zhong Chen/'s group published in Autophagy
2014-10-01
In July 2014, Dr. Chen Zhong Research Group published their recent work on a novel neuroprotection of ER stress against cerebral ischemia by regulating autophagy. The present work is a successive investigation of a previous paper which was also published in this journal. Cerebral ischemia is a leading cause of mortality and disability with few therapy. The patholgical mechanisms and potential ther... In July 2014, Dr. Chen Zhong Research Group publi
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Dr. Zhong Chen/'s group published in Biomaterials
2014-09-18
In August 2014, Dr. Chen Zhong Research Group published their recent work on the morphology and function of astrocytes cultured on water-repellent fractal tripalmitin surface. This work also obtained China Invention Patent. In the CNS, astrocytes play an essential role with their multiple functions and sophisticated structure, as surrounded by a fractal environment which hasn't been available ... In August 2014, Dr. Chen Zhong Research Group pub
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Dr. Aimin Bao/'s group published in Psychoneuroendocrinology
2014-09-16
Previous studies have observed that the gaseous neurotransmitter nitric oxide (NO) and the neuronal NO synthase (NOS1) are involved in the pathogenesis of depression. The chronic unpredictable stress (CUS) rats model is one of the important models to study the pathogenesis of depression. It remained, however, unclear whether the CUS model may show similar molecular changes, such as alterations in ... Previous studies have observed that the gaseous n
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Dr. Jizeng Du/'s group published in PNAS
2014-09-09
Chen, S.J., J.F. Yang, F.P. Kong, J.L. Ren, K. Hao, M. Li, Y. Yuan, X.C. Chen, R.S. Yu, J.F. Li, G. Leng, X.Q. Chen, and J.Z. Du. 2014. Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema. Proc Natl Acad Sci U S A 111:13199-13204. Abstract: Cerebral edema is a potentially life-threatening illness, but knowledge of its underly... Chen, S.J., J.F. Yang, F.P. Kong, J.L. Ren, K. Ha
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Dr. Jizeng Du and Xuequn Chen/'s group published in Proc Natl Acad Sci U S A
2014-07-24
Chen SJ, Yang JF, Kong FP, Ren JL, Hao K, Li M, Yuan Y, Chen XC, Yu RS, Li JF, Leng G, Chen XQ, Du JZ. Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema.Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13199-204. Abstract: Cerebral edema is a potentially life-threatening illness, but knowledge of its underlying mechanisms is limited. Her... Chen SJ, Yang JF, Kong FP, Ren JL, Hao K, Li M, Y
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Dr. Zhong Chen/'s group published in Angewandte Chemie International Edition
2014-07-18
July 2014, a research group headed by Professor Chen Zhong at Institute of Pharmacology, College of pharmaceutical sciences, Zhejiang University has recently published a research paper “Angiopep-conjugated Electro-responsive Hydrogel Nanoparticles: Therapeutic Potential for Epilepsy” in the journal “Angewandte Chemie International Edition”. The article reported that Angiope... July 2014, a research group headed by Professor C
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Dr. Shumin Duan and Dr. Yan-Qin Yu/'s group published in Cerebral Cortex
2014-04-15
On April 15, 2014, a paper titled Long-Term Synaptic Plasticity in Rat Barrel Cortex was published in Cerebral Cortex. It's accomplished by the lab of Duan Shumin in the neuroscience institute of Zhejiang University. Rats generate sweeping whisker movements in order to explore their environments and identify objects. In somatosensory pathways, neuronal activity is modulated by the frequency of... On April 15, 2014, a paper titled Long-Term Synap
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Dr. Shumin Duan and Dr. Yan-Qin Yu/'s group published in Current Biology
2014-03-06
On March 6, 2014, a paper titled Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep-wake Transitions was published in Current Biology. It's accomplished by the lab of Duan Shumin in the neuroscience institute of Zhejiang University. The basal forebrain (BF) plays a crucial role in cortical activation. However, the exact role of cholinergic BF (ch-BF) neurons in... On March 6, 2014, a paper titled Selective Activa
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Dr. Shumin Duan ’s group published in Nature Protocols
2014-02-26
Microglia are the primary immune cells in the central nervous system and play important roles in maintaining brain homeostasis. Directed microglial migration to the injured/disease sites in the brain, is key to the microglial immunoresponses and has been implicated in pathogenesis of multiple brain diseases. To investigate microglial migration, Prof. Duan’s group developed an approach ... Microglia are the primary immune cells in the cen
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Dr. Zhong Chen/'s group published in Nature Communications
2014-02-25
Recently, a research group headed by Prof. Chen Zhong at Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China and Zhejiang Province Key Laboratory of Neurobiology, College of pharmaceutical sciences, Zhejiang University has published a research paper titled “Histamine H3 receptors aggravate cerebral ischemic injury by histamine-independent mec... Recently, a research group headed by Prof. Chen Z
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Dr. Aimin Bao/'s group published in Cerebral Cortex
2013-12-17
Shang-Feng Gao, Xin-Rui Qi, Juan Zhao, Rawien Balesar, Ai-Min Bao* and Dick F. Swaab. Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression. Cerebral Cortex 2013; 23: 2956–2964. Abstract : Decreased function of the anterior cingulate cortex (ACC) is crucially involved in the pathogenesis of depression. A key role of nitric oxide (NO) has also been proposed. We aimed t... Shang-Feng Gao, Xin-Rui Qi, Juan Zhao, Rawien Bal
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Dr. Shumin Duan and Dr. Xiaoming Li/'s group published in J Neurosci
2013-12-16
Jian-Ming Yang,Jing Zhang, Xiao-Juan Chen,Hong-Yan Geng,Mao Ye, Nicholas C. Spitzer2, Jian-Hong Luo,Shu-Min Duan,Xiao-Ming Li. Abstract: erbb4 is a susceptibility gene for schizophrenia and ErbB4 signals have been hypothesized to function in a number... Jian-Ming Yang,Jing Zhang, Xiao-Ju
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Dr. Jizeng Du and Xuequn Chen/'s group published in Mol Cell Endocrinol
2013-09-11
Zhang S, Zhao Y, Hu X, Liu Z, Chen X, Chen X, Du J.Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus. Mol Cell Endocrinol. 2013 Aug 25;376(1-2):33-42. doi: 10.1016/j.mce.2013.05.025. Epub 2013 Jun 6. Abstract: Our previous study revealed the particular expression patterns of insulin-like growth factor 1 (IGF1)... Zhang S, Zhao Y, Hu X, Liu Z, Chen X, Chen X, Du
