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Dr. Shumin Duan/'s group published in the Jounal of Neuroscience
2015-04-13
A study from Professor Shumin Duan’s group on how an intracellular size filter enhances antigen processing in microglia was recently published on The Journal of Neuroscience Abstract: Microglia are the primary immune cells in the brain. Theycontinually survey the brain microenvironment and uptake cell debris and aberrant proteins to maintain brain homeostasis. Recent studies have shown that... A study from Professor Shumin Duan’s group
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Dr. Jizeng Du and Xuequn Chen/'s group published in Diabetes
2015-03-31
Hao K, Kong FP, Gao YQ, Tang JW, Chen J, Evans AM, Lightman SL, Chen XQ, Du JZ . Inactivation of Corticotropin-Releasing Hormone-Induced Insulinotropic Role by High-Altitude Hypoxia..Diabetes. 64: 785-795.2014 Abstract: We have shown that hypoxia reduces plasma insulin, which correlates with corticotropin-releasing hormone (CRH) receptor 1 (CRHR1) in rats, but the mechanis... Hao K, Kong FP, Gao YQ, Tang JW, Chen J, Evans AM
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Dr. Ying Shen/'s group published in Scientific Reports (NPG)
2015-01-20
On Jan 16 2015, Scientific Reports(Nature Publishing Group) published an original research article from Ying Shen’s group. The title is “Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum”. In the textbook, LGI1 is a classical gene that is tightly linked to human autosomal dominant lateral temporal lobe epilepsy (ADLTE). ... On Jan 16 2015, Scientific Reports(Nature Publish
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Dr. Jianhong Luo/'s group published in Cell Death and Disease
2014-12-02
TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death Dis. 2014 Nov 27. Abstract: Transient ischemia is a leading cause of cognitive dysfunction. Postischemic ROS generation and an increase in the cytosolic Zn2+ level ([Zn2+]c) are critical in delayed CA1 pyramidal neuronal death, but the underlying mechan... TRPM2 channel deficiency prevents delayed cytosol
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Dr. Zhong Chen/'s group published in Autophagy
2014-10-01
In July 2014, Dr. Chen Zhong Research Group published their recent work on a novel neuroprotection of ER stress against cerebral ischemia by regulating autophagy. The present work is a successive investigation of a previous paper which was also published in this journal. Cerebral ischemia is a leading cause of mortality and disability with few therapy. The patholgical mechanisms and potential ther... In July 2014, Dr. Chen Zhong Research Group publi
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Dr. Zhong Chen/'s group published in Biomaterials
2014-09-18
In August 2014, Dr. Chen Zhong Research Group published their recent work on the morphology and function of astrocytes cultured on water-repellent fractal tripalmitin surface. This work also obtained China Invention Patent. In the CNS, astrocytes play an essential role with their multiple functions and sophisticated structure, as surrounded by a fractal environment which hasn't been available ... In August 2014, Dr. Chen Zhong Research Group pub
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Dr. Aimin Bao/'s group published in Psychoneuroendocrinology
2014-09-16
Previous studies have observed that the gaseous neurotransmitter nitric oxide (NO) and the neuronal NO synthase (NOS1) are involved in the pathogenesis of depression. The chronic unpredictable stress (CUS) rats model is one of the important models to study the pathogenesis of depression. It remained, however, unclear whether the CUS model may show similar molecular changes, such as alterations in ... Previous studies have observed that the gaseous n
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Dr. Jizeng Du/'s group published in PNAS
2014-09-09
Chen, S.J., J.F. Yang, F.P. Kong, J.L. Ren, K. Hao, M. Li, Y. Yuan, X.C. Chen, R.S. Yu, J.F. Li, G. Leng, X.Q. Chen, and J.Z. Du. 2014. Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema. Proc Natl Acad Sci U S A 111:13199-13204. Abstract: Cerebral edema is a potentially life-threatening illness, but knowledge of its underly... Chen, S.J., J.F. Yang, F.P. Kong, J.L. Ren, K. Ha
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Dr. Jizeng Du and Xuequn Chen/'s group published in Proc Natl Acad Sci U S A
2014-07-24
Chen SJ, Yang JF, Kong FP, Ren JL, Hao K, Li M, Yuan Y, Chen XC, Yu RS, Li JF, Leng G, Chen XQ, Du JZ. Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema.Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13199-204. Abstract: Cerebral edema is a potentially life-threatening illness, but knowledge of its underlying mechanisms is limited. Her... Chen SJ, Yang JF, Kong FP, Ren JL, Hao K, Li M, Y
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Dr. Zhong Chen/'s group published in Angewandte Chemie International Edition
2014-07-18
July 2014, a research group headed by Professor Chen Zhong at Institute of Pharmacology, College of pharmaceutical sciences, Zhejiang University has recently published a research paper “Angiopep-conjugated Electro-responsive Hydrogel Nanoparticles: Therapeutic Potential for Epilepsy” in the journal “Angewandte Chemie International Edition”. The article reported that Angiope... July 2014, a research group headed by Professor C
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Dr. Shumin Duan and Dr. Yan-Qin Yu/'s group published in Cerebral Cortex
2014-04-15
On April 15, 2014, a paper titled Long-Term Synaptic Plasticity in Rat Barrel Cortex was published in Cerebral Cortex. It's accomplished by the lab of Duan Shumin in the neuroscience institute of Zhejiang University. Rats generate sweeping whisker movements in order to explore their environments and identify objects. In somatosensory pathways, neuronal activity is modulated by the frequency of... On April 15, 2014, a paper titled Long-Term Synap
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Dr. Shumin Duan and Dr. Yan-Qin Yu/'s group published in Current Biology
2014-03-06
On March 6, 2014, a paper titled Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep-wake Transitions was published in Current Biology. It's accomplished by the lab of Duan Shumin in the neuroscience institute of Zhejiang University. The basal forebrain (BF) plays a crucial role in cortical activation. However, the exact role of cholinergic BF (ch-BF) neurons in... On March 6, 2014, a paper titled Selective Activa
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Dr. Shumin Duan ’s group published in Nature Protocols
2014-02-26
Microglia are the primary immune cells in the central nervous system and play important roles in maintaining brain homeostasis. Directed microglial migration to the injured/disease sites in the brain, is key to the microglial immunoresponses and has been implicated in pathogenesis of multiple brain diseases. To investigate microglial migration, Prof. Duan’s group developed an approach ... Microglia are the primary immune cells in the cen
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Dr. Zhong Chen/'s group published in Nature Communications
2014-02-25
Recently, a research group headed by Prof. Chen Zhong at Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China and Zhejiang Province Key Laboratory of Neurobiology, College of pharmaceutical sciences, Zhejiang University has published a research paper titled “Histamine H3 receptors aggravate cerebral ischemic injury by histamine-independent mec... Recently, a research group headed by Prof. Chen Z
