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Junyu Xu's group published in eLife
2022-02-28
Dynamic microtubules play a critical role in cell structure and function. In nervous system, microtubules are the major route for cargo protein trafficking and they specially extend into and out of synapses to regulate synaptic development and plasticity. However, the detailed depolymerization mechanism that regulates dynamic microtubules in synapses and dendrites is still unclear. In this study, ...Dynamicmicrotubulesplayacriticalroleincellstructureandfunction.Innervoussystem,microtubulesarethemajorrouteforcargoproteintraffickingandtheyspeciallyextendintoandoutofsynapsestoregulatesynapticdevelopmentandplasticity.However,thedetaileddepolymerizationmechanismthatregulatesdynamicmicrotubulesinsynapsesanddendritesisstillunclear.Inthisstudy,wefindthatKIF2C,adynamicmicrotubuledepolymerizationproteinwithoutknownfunctioninthenervoussystem,playsapivotalroleinthestructuralandfunctionalplasticityofsyn
