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Shumin Duan's group published in Science Advances
2021-01-05
The research team led by Prof. Shumin Duan has recently published an article titled Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD in Science Advanceson Dec 9th, Beijing time. This research uncovered a novel role of endosomal/lysosomal vesicles in regulating actin-cytoskeleton dynamics during ATP signaling-evoked microglia migration.Organelle...TheresearchteamledbyProf.ShuminDuanhasrecentlypublishedanarticletitledLateendosomespromotemicrogliamigrationviacytosolictranslocationofimmatureproteasecathDinScienceAdvancesonDec9th,Beijingtime.Thisresearchuncoveredanovelroleofendosomal/lysosomalvesiclesinregulatingactin-cytoskeletondynamicsduringATPsignaling-evokedmicrogliamigration.Organelletransportrequiresdynamiccytoskeletonremodeling,butwhethercytoskeletaldynamicsare,inturn,regulatedbyorganellesremainselusive.Thisworkdemonstratesthatlateend
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Dr. Xiao-Dong Wang's group published in Nature Communications
2021-01-04
Touch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. We report that tactile experience enrichment improves memory and alleviates anxiety by remodeling neurons along the dorsoventral axis of the dentate gyrus (DG) in adult mice. Tactile enrichment induces differential activation and structural modification of neurons in the dorsal and ventral DG, and i...Touchcanpositivelyinfluencecognitionandemotion,buttheunderlyingmechanismsremainunclear.Wereportthattactileexperienceenrichmentimprovesmemoryandalleviatesanxietybyremodelingneuronsalongthedorsoventralaxisofthedentategyrus(DG)inadultmice.TactileenrichmentinducesdifferentialactivationandstructuralmodificationofneuronsinthedorsalandventralDG,andincreasesthepresynapticinputfromthelateralentorhinalcortex(LEC),whichisreciprocallyconnectedwiththeprimarysomatosensorycortex(S1),totactileexperience-activat
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Binggui Sun's group published in Stem Cell Reports
2021-01-04
Adult neurogenesis is impaired in the hippocampus of patients with Alzheimer disease (AD) as well as AD models. However, it is far from clear how modulating adult neurogenesis affects AD neuropathology. A team led by Dr. Binggui Sun, a principal investigator at Zhejiang University School of Brain Science and Brain Medicine, reported that inhibiting adult neurogenesis improved synaptic and cognitiv...AdultneurogenesisisimpairedinthehippocampusofpatientswithAlzheimerdisease(AD)aswellasADmodels.However,itisfarfromclearhowmodulatingadultneurogenesisaffectsADneuropathology.AteamledbyDr.BingguiSun,aprincipalinvestigatoratZhejiangUniversitySchoolofBrainScienceandBrainMedicine,reportedthatinhibitingadultneurogenesisimprovedsynapticandcognitivefunctionsinmousemodelsofAD.Theirnewpaperentitled“DeletingAdultNeuralStemCellsImprovesSynapticandCognitiveFunctionsinAlzheimerModels”appearedonlineinStemCellRe
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Yanqin Yu and Shumin Duan's group published in eLife
2020-09-23
The research team led by Prof. Yanqin Yu and Shumin Duan has recently published an article titled “Activation of Astrocytes in Hippocampus Decreases Fear Memory through Adenosine A1 Receptors” on eLife online (DOI: 10.7554/eLife.57155) on September 1, 2020, Beijing time (September 21, 2020, full online edition). This research uncovered how astrocyte activity regulates context...TheresearchteamledbyProf.YanqinYuandShuminDuanhasrecentlypublishedanarticletitled“ActivationofAstrocytesinHippocampusDecreasesFearMemorythroughAdenosineA1Receptors”oneLifeonline(DOI:10.7554/eLife.57155)onSeptember1,2020,Beijingtime(September21,2020,fullonlineedition).Thisresearchuncoveredhowastrocyteactivityregulatescontextualfearmemory,thedysregulationofwhichleadstopathologicalfear-relateddisorders.Astrocytesrespondtoandregulateneuronalactivity,yettheirroleinmammalianbehaviorremainsincompletely
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Zhihua Gao and Shumin Duan's group published in Glia
2020-06-10
On November 21, 2019, Glia published a study from Zhihua Gao and Shumin Duan’s group. The study, entitled “mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP”, demonstrated different metabolic adaptations contribute to the distinct immunoresponses and functional states of microglia and suggest that mTOR is an important target...OnNovember21,2019,GliapublishedastudyfromZhihuaGaoandShuminDuan’sgroup.Thestudy,entitled“mTOR-mediatedmetabolicreprogrammingshapesdistinctmicrogliafunctionsinresponsetolipopolysaccharideandATP”,demonstrateddifferentmetabolicadaptationscontributetothedistinctimmunoresponsesandfunctionalstatesofmicrogliaandsuggestthatmTORisanimportanttargettomanipulatemicroglialmetabolismandfunction.Microgliaconstantlysurveythemicroenvironmenttomaintainbrainhomeostasisunderphysiologicalconditions.Uponinjuriesordis
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Hailan Hu's group published in Nature Reviews Neuroscience
2020-05-06
The research team led by Hailan Hu has recently published a review titled Circuits and Functions of the Lateral Habenula in Health and in Disease on Nature Reviews Neuroscience online on April 8th. This review provides an update on the basic organization of the lateral habenula (LHb), and describes various physiological functions of LHb and the relevance of the LHb in major psychiatric disorders. ...TheresearchteamledbyHailanHuhasrecentlypublishedareviewtitledCircuitsandFunctionsoftheLateralHabenulainHealthandinDiseaseonNatureReviewsNeuroscienceonlineonApril8th.Thisreviewprovidesanupdateonthebasicorganizationofthelateralhabenula(LHb),anddescribesvariousphysiologicalfunctionsofLHbandtherelevanceoftheLHbinmajorpsychiatricdisorders.Thepastdecadehaswitnessedexponentiallygrowinginterestinthelateralhabenula(LHb)owingtonewdiscoveriesrelatingtoitscriticalroleinregulatingnegativelymotivatedbehaviour
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Prof.Wei Yang's group published on Cell Reports
2019-06-18
cADPR is a well-recognized signaling molecule by modulating the RyRs, but considerable debate exists regarding whether cADPR can bind to and gate the TRPM2 channel, which mediates oxidative stress signaling in diverse physiological and pathological processes. Here, we show that purified cADPR evoked TRPM2 channel currents in both whole-cell and cell-free single-channel recordings and specific bind... cADPR is a well-recognized signaling molecule by
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Prof.Wei Gong's group published on PNAS
2019-05-18
Optical clearing is a versatile approach to improve imaging quality and depth of optical microscopy by reducing scattered light.However, conventional optical clearing methods are restricted in the efficiency-first applications due to unsatisfied time consumption, irreversible tissue deformation, and fluorescence quenching.Here, we developed an ultrafast optical clearing method (FOCM) with simple p... Optical clearing is a versatile approach to impro
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Prof.Xiaoming Li’s group published on Nature Neuroscience
2019-05-05
The research team led by Prof. Xiaoming Li has recently published an article titled A novel cortico-intrathalamic circuit for flight behavior on Nature Neuroscience online on April 29th at 23pm, Beijing time. This research uncovered a neural circuit from cortex to thalamus mediated by Thalamic reticular nucleus(TRN) which is involved in regulating flight behavior induced by fear. More importantly,... The research team led by Prof. Xiaoming Li has re
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Prof.Zhong Chen’s group published on Journal of Cell Biology
2019-04-13
Tens of millions of people suffer from cerebral ischemia worldwide，whereas unfortunately, limited clinical approaches are available in the current stage due to the extremely complicated pathological mechanisms of ischemic injury and a lack of precise therapeutic targets. Neuronal death induced by the sudden shortage of blood supply is one of the major outcomes of cerebral ischemia. Neurons serve ... Tens of millions of people suffer from cerebral i
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Dr. Yan Zhang/'s group published in Science
2019-04-12
In a research article published on April 12, 2019 in Science titled “Structure and Dynamics of the Active Human Parathyroid Hormone Receptor-1” (DOI: 10.1126/science.aav7942), scientists at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences led by Huaqiang Eric Xu and Ming-Wei Wang, Zhejiang University School of Basic Medical Sciences led by Yan Zhang and University ... In a research article published on April 12, 2019
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Dr. Han Xu/'s group published in Neuron
2019-03-19
A research team led by Han Xu, a professor of neurobiology at Zhejiang University School of Medicine has uncovered a previously unknown neuronal circuitry that mediates social fear behavior. The research is entitled “A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex” andpublished online in Neuron on March 18th. Professor Han Xu is the corresponding ... A research team led by Han Xu, a professor of neu
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Dr. Yudong Zhou/'s group published in Nature Communications
2019-03-17
On Mar 13, 2019, Professor Yudong Zhou’s research group from Zhejiang University in China published a research article entitled “Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate” (Yang He, et al.)in the journal Nature Communications. Amyloid β (Aβ) oligomer-induced aberrant neurotransmitt... On Mar 13, 2019, Professor Yudong Zhou’s re
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Dr. Shumin Duan’s group published in Brain
2019-01-27
On March 1, 2019, Brain published a study from Dr. Shumin Duan’s research group. The study, entitled “CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signaling”, investigated how adenosine metabolism pathway regulates microglia-mediated neuroinflammation and affects the progression of a Parkinson disease model. Microglia-mediated n... On March 1, 2019, Brain published a study from Dr
