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Dr. Ying Shen/'s Team published in Journal of Neuroscience
2018-03-21
On 2/28/2018, the Journal of Neuroscience published online a research article entitled “Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy” from Prof. Shen’s group. This study reveals that the cause of seizures in Autosomal Dominant Lateral Temporal Lobe Epilepsy (ADLTE) is the increased discharges of cortical pyramidal neurons, the under... On 2/28/2018, the Journal of Neuroscience publish
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Two back-to-back Nature Articles form Hailan Hu/'s Team on Depression and Ketamine
2018-02-15
On Feb 14, 2018, Nature published online two Research Articles side-by-side from Professor Hailan Hu’s team in the Medical School of Zhejiang University. They reported a series of discoveries pertaining the rapid antidepressant mechanism of ketamine, the abnormal neural coding pattern and neuron-glia interaction underlying depression. Classical antidepressants... On Feb 14, 2018, Nature published online&n
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Dr. Hailan Hu/'s Team published in Science
2017-07-14
Getting to the top of social hierarchy is often not a matter of body size or brute strength, but rather determined by intrinsic mental factors such as grit, as well as extrinsic factors such as history of winning. For example, social dominance can be reinforced by a phenomenon known as the “winner effect”, whereby animals increase their probability of victory after previous winnings. H... Getting to the top of social hierarchy is often n
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Dr. Weiping Zhang/'s group published in PNAS
2017-06-19
Dong X, Gong Z, Lu Y B, Liu K, Qin L Y, Ran M L, Zhang C L, Liu Z, Zhang W P, and Tang C. Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci U S A, 2017 Jun 13. Abstract: Ubiquitin (Ub) is an important signaling protein. Recent studies showed that Ub can be enzymatically phosphorylated at S65, and the resulting pUb exhibits t... Dong X, Gong Z, Lu Y B, Liu K, Qin L Y, Ran M L,
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Dr.Binggui Sun/'s group published in FASEB Journal
2017-03-06
A new study from laboratories of Dr. Binggui Sun and collaborators demonstrated that brain-specific ablation of Efr3a promoted adult hippocampal neurogenesis via brain derived neurotrophic factor pathway. Efr3 is a newly identified plasma membrane protein and plays an important role in the phosphoinositide metabolism on the plasma membrane. However, although it is highly expressed in the br... A new study from laboratories of Dr. Bingg
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Dr. Shumin Duan/'s group published in Nature Communication
2017-02-06
Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Tan, Z. Liu Y, Xi W, Lou HF, Zhu L, Guo Z, Mei L, Duan. Nat. Commun. 8, 13772 doi: 10.1038/ncomms13772 (2017). Abstract: Astrocyte responds to neuronal activity with calcium waves and modulates synaptic transmission through the release of gliotransmitters. However, little is known a... Glia-derived ATP inversely regulates excitability
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Dr. Yudong Zhou/'s group published in Journal of Cell Biology
2016-11-10
Shen Y, Qin H, Chen J, Mou L, He Y, Yan Y, Zhou H, Lv Y, Chen Z, Wang J, Zhou YD.Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons.J Cell Biol. 2016 Dec 5;215(5):719-734. Epub 2016 Nov 10. Abstract: Astrocytes are critical in synapse development, and their dy... Shen Y, Qin H, Chen J, Mou L,
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Dr. Zhong Chen/'s group published in Pain
2016-10-15
ZhangSH, YuJ, LouGD, TangYY, WangRR, HouWW, Chen Z.Widespread pain sensitization after partial infraorbital nerve transection in MRL/MPJ mice.Pain. 2016 Mar;157(3):740-9. Abstract: Clinical studies show that chronic pain can spread to adjacent or even distant body regions in some patients. However, little is known about ho... ZhangSH, YuJ, LouGD, TangYY,
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Dr. Zhong Chen/'s group published in Brain Behavior and Immunity
2016-10-14
Zhou Y, Zhang J, Wang L, Chen Y, Wan Y, He Y, Jiang L, Ma J, Liao R, Zhang X, Shi L, Qin Z, Zhou Y, Chen Z, Hu W.Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.Brain Behav Immun. 2016 Sep 20. Abstract: Subcortical ische... Zhou Y, Zhang J, Wang L, Chen
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Dr. Shumin Duan and Dr. Hao Wang/'s group published in eLife
2016-04-13
Yang J, Yang H, Liu Y, Li X, Qin L, Lou H, Duan S, Wang H.Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP.Elife. 2016 Apr 12;5:e15043. doi: 10.7554/eLife.15043. Abstract: Selective elimination of unwanted synapses is vital for the precise formation of neuronal circuits during development,... Yang J, Yang H, Liu Y, Li X,
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Dr. Xiaoming Li/'s group published in eLife
2016-02-12
Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. Kun-Ming Ni, Xiao-Jun Hou, Ci-Hang Yang, Ping Dong, Yue Li, Ying Zhang, Ping Jiang, Darwin K Berg, Shumin Duan, Xiao-Ming Li. DOI: http://dx.doi.org/10.7554/eLife.10382 Abstract: Cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (... Selectively driving cholinergic fibers optically
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Dr. Shumin Duan and Dr. Hao Wang/'s group published in Nature Neuroscience
2016-01-05
Yang H, Yang J, Xi W, Hao S, Luo B, He X, Zhu L, Lou H, Yu YQ, Xu F, Duan S, Wang H.Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.Nat Neurosci. 2016 Feb;19(2):283-9. doi: 10.1038/nn.4208. Epub 2016 Jan 4. Abstract: Innate fear has a critical role in survival of animal... Yang H, Yang J, Xi W, Hao S,
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Dr. Zhefeng Gong/'s group published in Nature Communication
2015-12-17
Li Q, Gong Z. Cold-sensing regulates Drosophila growth through insulin-producing cells.Nat Commun. 2015 Dec 9;6:10083. Abstract: Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger body sizes than those observed at higher temperatures. The underlying molecular basis of this effect is poorly understood. Here we provide ev... Li Q, Gong Z. Cold-sensing regulates Drosoph
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Dr. Ying Shen/'s group published in PNAS
2015-12-03
Zhou L, Yang D, Wang DJ, Xie YJ, Zhou JH, Zhou L, Huang H, Han S, Shao CY, Li HS, Zhu JJ, Qiu MS, De Zeeuw CI, Shen Y. Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination. Proc Natl Acad Sci U S A. 2015 Nov 30. pii: 201512915. Abstract: Protein Numb controls cell fate by interacting with a number of signaling molecules,... Zhou L, Yang D, Wang DJ, Xie YJ, Zhou JH, Zhou L,
