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Junyu Xu's group published in eLife
2022-02-28
Dynamic microtubules play a critical role in cell structure and function. In nervous system, microtubules are the major route for cargo protein trafficking and they specially extend into and out of synapses to regulate synaptic development and plasticity. However, the detailed depolymerization mechanism that regulates dynamic microtubules in synapses and dendrites is still unclear. In this study, ...Dynamicmicrotubulesplayacriticalroleincellstructureandfunction.Innervoussystem,microtubulesarethemajorrouteforcargoproteintraffickingandtheyspeciallyextendintoandoutofsynapsestoregulatesynapticdevelopmentandplasticity.However,thedetaileddepolymerizationmechanismthatregulatesdynamicmicrotubulesinsynapsesanddendritesisstillunclear.Inthisstudy,wefindthatKIF2C,adynamicmicrotubuledepolymerizationproteinwithoutknownfunctioninthenervoussystem,playsapivotalroleinthestructuralandfunctionalplasticityofsyn
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Huan Ma's group published in Cell Reports
2021-07-23
The research team led by Prof. Huan Ma has recently published an article titled Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD on Cell Reports online on July 20, 2021 at 11am, ET. Cellular resources must be reorganized for long-term synaptic plasticity during brain information processing, in which coordinated gene transcript...TheresearchteamledbyProf.HuanMahasrecentlypublishedanarticletitledNeuronalactivityrecruitstheCRTC1/CREBaxistodrivetranscription-dependentautophagyformaintaininglate-phaseLTDonCellReportsonlineonJuly20,2021at11am,ET.Cellularresourcesmustbereorganizedforlong-termsynapticplasticityduringbraininformationprocessing,inwhichcoordinatedgenetranscriptionandproteinturnoverarerequired.However,themechanismunderlyingthisprocessremainselusive.Here,wereportthatactivatingNMDARsinducestranscription-dependentauto
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