Semilar: The stressed hippocampus and lost memories: focusing on the CRH-CRHR1 system and synaptic a
2013-05-07
Zhejiang University
Pageviews: 973
Speaker: Dr. Xiaodong Wang
Time：2013.5.7. 1:30-2:30pm
Venue：B502
Repeated exposure to severely stressful events either early in life or in adulthood may negatively influence brain function, learning and memory. It has been proposed that central corticotropin-releasing hormone (CRH), one of the key stress mediators, modulates the physiological and behavioral effects of chronic stress in different life stages via the corticotropin-releasing hormone receptor 1 (CRHR1). However, direct evidence linking augmented CRH-CRHR1 signaling to stress-induced cognitive impairments and structural remodeling is scarce.
The present talk will focus on the involvement of forebrain CRHR1 signaling in modulating the consequences of chronic stress on hippocampus-dependent learning and memory as well as hippocampal integrity. Moreover, the potential roles of synaptic cell adhesion molecules, especially nectins, in these processes and their interactions with the CRH-CRHR1 system will be discussed.
