Seminar: In Sights into Human Aging Based on Pluripotent Stem Cells and Gene Target Modification
**Speaker: Guanghui Liu, PhD
**Time: Jan 17, 2013, 2:30 pm
**Place: Research Building, Room B502, School of Medicine
**Speaker Brief Introduction:
Guanghui Liu, PhD
Professor, Institute of Biophysics, Chinese Academy of Sciences
Education and Research Experience
1997-2002，B.S., Peking University Health Science Center
2002-2007，Ph.D., Institute of Biophysics, Chinese Academy of Sciences
2007-2009，Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute
2009-2011，Research associate, Gene expression laboratory, The Salk Institute for Biological Studies
2010-2011，CIRM scholar, California Institute of Regenerative Medicine (CIRM)
2011-，Glenn fellow, Glenn Aging Foundation
2011-，Professor, Institute of Biophysics, Chinese Academy of Sciences
2012，Thousand Young Talents program of China
Research Interests
1. Modeling human diseases with pluripotent stem cells (PSCs)
2. Editing human genome in hPSCs
3. Mechanism of human aging and longevity
4. Nuclear architecture, chromatin organization, and human diseases
Representative publications
(1equal contribution; *Corresponding author)
1.Liu GH1*, Qu J1, Suzuki K1, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Ren B, Wagner U, Kim A, Li Y, Goebl A, Kim J, Soligalla R, Dubova I, Thompson J, Yates J III, Esteban C, Sancho-Martinez I, Belmonte JC*. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.Nature. 2012; 491(7425):603-7.
2. Pan H1, Cai N1, Li M, Liu GH*, Izpisua Belmonte JC*. Autophagic control of cell stemness. EMBO Mol. Med. 2013. In press
3. Liu GH1*, Ding Z1, Izpisua Belmonte JC*. iPSC technology to study human aging and aging-related disorders.Curr Opin Cell Biol. 2012; Dec;24(6):765-74
4. Li M1, Liu GH1, Belmonte JC.Navigating the epigenetic landscape of pluripotent stem cells.Nat Rev Mol Cell Biol.2012; 13(8):524-35.
5. Liu GH1, Suzuki K1, Qu J1, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring J,Laurent L, and Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011; 8(6):688-94
6.Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, III JY, Belmonte JC. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011; 14;472: 221-5
